Public Health action
Notifiable disease data and reports
Both confirmed and probable cases should be notified.
A) Confirmed case
A confirmed case requires laboratory definitive evidence and clinical evidence.
Laboratory definitive evidence
1. Isolation of dengue virus
2. Detection of dengue virus by nucleic acid testing
3. Detection of dengue non-structural protein 1 (NS1) antigen in blood
4. IgG seroconversion or a significant increase in antibody level or a fourfold or greater rise in titre to dengue virus, proven by neutralisation or another specific test
5. Detection of dengue virus-specific IgM in cerebrospinal fluid, in the absence of IgM to Murray Valley encephalitis, West Nile/Kunjin, or Japanese encephalitis viruses
Confirmation of laboratory result by a second arbovirus reference laboratory is required if the infection was locally acquired and occurred in an area of Australia without known local transmission of dengue fever since 1990 (for example anywhere outside north Queensland).
A clinically compatible illness (eg fever, headache, arthralgia, myalgia, rash, nausea, and vomiting, with a possible progression to severe plasma leakage, severe haemorrhage, or severe organ impairment-CNS, liver, heart or other).
B) Probable case
A probable case requires laboratory suggestive evidence and clinical evidence and epidemiological evidence.
Laboratory suggestive evidence
Detection of dengue virus-specific IgM in blood
As for confirmed case
A plausible explanation, e.g. travel to a country with known dengue activity or exposure in Australia where local transmission has been documented within the previous month.